Antibiotic Material Tolnaftate Powder Tolnaftate

• Overview
• Product Description
• Product Details
• Application&Function
• Specification

Overview

Basic Info.

Model NO.	XMHT-Tolnaftate
Certification	GMP, HSE, ISO 9001, USP, BP
Suitable for	Elderly, Children, Adult
State	Powder
Purity	>99%
Puduct Name	Tolnaftate
Name	Tolnaftate Powder
Appreance	White Powder
Colour	White
Application	Pharmaceutical
Grade	Pharmaceutical Grade
CAS	2398-96-1
Mf	C19h17nos
MW	307.411
Density	1.223
Melting Point	110.5-111.5ºC
Specific	COA
Sjhelf Life	2years
Assay	≥ 99.0%
Test Method	HPLC
Transport Package	Negotiable
Specification	≥ 99.0%
Trademark	XMHT
Origin	Shanxi Xi'an
Production Capacity	3000kg/Month

Product Description

Antibiotic Material Tolnaftate Powder TolnaftateProduct Description

Product Details

Product Name	Tolnaftate
Appearance	White Powder
CAS	2398-96-1
MF	C19H17NOS
MW	307.411

Tolnaftate is a well-established and highly effective topical antifungal agent specifically designed to combat superficial dermatophyte infections in both livestock and companion animals. Its primary mechanism of action involves the selective inhibition of a key fungal enzyme, squalene epoxidase, which plays an absolutely critical role in the early stages of ergosterol biosynthesis within the fungal cell membrane. Ergosterol is the functional equivalent of cholesterol in mammalian cells; it is an essential sterol component that maintains the structural integrity, fluidity, and functionality of the fungal cell membrane.Application&Function

By blocking the conversion of squalene to squalene epoxide, Tolnaftate causes a dual detrimental effect on the fungal pathogen. Firstly, it leads to a critical deficiency of ergosterol in the growing cell membrane, compromising its structure and making it abnormally permeable and leaky. Secondly, the accumulation of the precursor substrate, squalene, within the fungal cell is itself toxic, contributing to rapid cell death. This targeted mechanism results in potent fungistatic and, at higher concentrations, fungicidal activity against a broad spectrum of dermatophytes, including the most common causative agents of ringworm such as Microsporum canis, Microsporum gypseum, and Trichophyton mentagrophytes. Its specificity for the fungal enzyme system means it has a high margin of safety and minimal risk of systemic absorption or toxicity when applied topically as directed.The clinical applications of Tolnaftate in veterinary practice are extensive and crucial for managing dermatophytosis, a common, contagious, and often stubborn skin condition. In companion animals, particularly in cats, dogs, and rabbits, ringworm outbreaks can spread rapidly in multi-animal households, shelters, and breeding facilities. The application of Tolnaftate in the form of creams, ointments, solutions, or sprays directly to the localized lesions, characterized by circular areas of alopecia, scaling, and inflammation, leads to a rapid reduction in fungal viability on the skin surface and within the hair shafts. Specification